Science has seen the Largest Eruption In the Known Universe Is ~100 Times the Size of Milky Way. A time in the future may see an eruption of this magnitude visit this neighborhood. All investments in space colonies, defenses against meteor impacts, and the extension of lifespan undone in an instant. Science has observed things large enough to overwhelm living spaces. Nothing physical lasts forever. Nature eventually restarts things at zero.
Tools of travel may be created to mitigate such things. Maybe tools will be devised as the means to calibrate gravity itself and control black holes. Could the creation of such things precipitate the destruction they would avoid? Anyway, it is a surprise to learn about things like ultra massive black holes that was once considered fictional exaggeration.
Ultimate safe boundaries in nature may be an illusion.